| 28-12-2021 |
Selectivity of capsaicin analogs to TRP receptores
Here we aim to find a set of useful pharmacological capsaicinoids matching potency, affinity, pharmacotechnical properties, significant water solubility, and oral bioavailability. To this end, we studied a large set of capsaicin-derived molecules by first considering the geometric complementarity, explored the effects of introducing modifications into capsaicin’s head region, provided extensive pharmacological predictions, and finally extended our predictions to vanilloid family members.
Prerequisites:
None.
Evaluation method: Nota 1-7, with 0/1 available vacants |
Mentor(s): Open in the plataform |